EMD Calpain Inhibitor I 5 Mg 208719-5MG w/ Free S&H

EMD Calpain Inhibitor I 5 Mg 208719-5MG is one of the many quality laboratory and scientific products we have to offer at very competitive pricing. EMD Calpain Inhibitor I 5 Mg 208719-5MG / 80055-570 is part of a wide selection of EMD Molecular biology and specialized reagents. Combining excellent quality with an affordable price, the EMD Calpain Inhibitor I 5 Mg 208719-5MG / 80055-570 can meet your scientific research needs while still offering a good value for a budget conscious end user. If you have any questions about any of our Molecular biology and specialized reagents please do not hesitate to contact our customer service for further guidance.

MG 101; N-acetyl-Leu-Leu-Nle-CHO

White solid.Inhibitor of calpain I (K_i=190nM), calpain II (K_i=220nM), cathepsin B (K_i=150nM) and cathepsin L (K_i=0.5nM). Inhibits neutral cysteine proteases and the proteasome (K_i=6µM). Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Also inhibits retrovirus-induced apoptosis in L929 cells. Inhibits the proteolysis of IkappaB-alpha and IkappaB-beta by the ubiquitin-proteasome complex. Inhibits cell cycle progression at G₁/S and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.

Purity: Single spot by TLC.Soluble in DMSO and ethanol.

FW: 383.5

CAS: 110044-82-1

Storage and Handling: Upon arrival, refrigerate at 4°C (39°F).

Literature References: Debiasi, R.L., et al. 1999. J. Virol.73, 965; Milligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388; Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun.215, 721.

Specifications for EMD Calpain Inhibitor I 5 Mg 208719-5MG:

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