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Liquid. In 150 mM NaCl, 100 mM potassium chloride, 50 mM sodium phosphate buffer, 500 mg/ml gentamycin sulfate, pH 7.5. Dimeric fusion protein consisting of the extracellular domain of human CD40 (193 amino acids) fused to murine IgG2a Fc (233 amino acids). Member of the TNF receptor family. Present on all B cells except plasma cells and on some epithelial cells, carcinomas, and lymphoid dendritic cells. Interaction with its ligand, CD154 (CD40 ligand) is important for isotype switching. Plays an important role in B cell activation. Purity: ³95% by SDS-PAGE.
Ref.: Ozaki, M.E., et al. 1997. J. Immunol.159, 214; Foy, T.A., et al. 1996. Annu. Rev. Immunol.14, 591.
Synonyms: not available
CAS: not available
MDL: MFCD02687015
Molecular Weight: 110,000
Merck Index: not available
| Description: | CD40-MUIG FUSION PROTEIN HUMA |
| Unit: | Each (25 UG) |