EMD Daunorubicin Hcl 5 Mg 251800-5MG w/ Free Shipping

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Daunomycin, HCl

Red crystalline solid.Potent anticancer agent whose potential target site may be mitochondrial cytochrome C oxidase. Has been shown to inhibit RNA and DNA synthesis. Inhibits eukaryotic topoisomerase I and II. Induces DNA single strand breaks. Induces apoptosis in HeLaS3 tumor cells.

Soluble in methanol and water.

C₂₇H₂₉NO₁₀•HCl

FW: 564.0

CAS: 23541-50-6

Merck Index: 12, 2890

Storage and Handling: Store at 20°C (68°F).

Warning: Harmful. LD₅₀ of <=2000mg/kg. May be carcinogenic/teratogenic.

Literature References: Friedenberg, W. R., et al. 1995. Am. J. Clin. Oncol.18, 105; Papadopoulou. L. C., and Tsiftsoglou, A. S. 1993. Cancer Res.53, 1072; Skladanowski, A., and Konopa, J. 1993. Biochem. Pharmacol.46, 375.

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