EMD Inhibitor FTI-276 250UG 344550-250UG w/ Free S&H

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Off-white solid. PROTECT FROM MOISTURE. PACKAGED UNDER INERT GAS. A highly potent and selective CAAX peptidomimetic of the carboxyl terminal of Ras proteins. Inhibitor of farnesyltransferase (FTase) in vitro (IC₅₀ = 500 pM). Inhibits geranylgeranyltransferase I (GGTase I) at much higher concentration (IC₅₀ = 50 nM). Has been shown to selectively block the growth of a human lung carcinoma expressing oncogenic K-Ras in nude mice. Also inhibits oncogenic signaling and tumor growth of NIH 3T3 cells transformed with the Ras oncogene at 20 mM. Purity: ³90% by HPLC.Supplied as a trifluoroacetate salt.

Ref.: Lantry, L.E., et al. 2000. Carcinogenesis21, 113; Lerner, E.C., et al. 1995. J. Biol. Chem.270, 26802; Sun, J., et al. 1995. Cancer Res.55, 4243.

Synonyms: not available

C₂₁H₂₇N₃O₃S₂

CAS: not available

MDL: MFCD03700738

Molecular Weight: 433.6

Merck Index: not available

Specifications for EMD Inhibitor FTI-276 250UG 344550-250UG:

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