EMD Inhibitor Monastrol 1MG 475879-1MG w/ Free Shipping

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4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic Acid Ethyl Ester

White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A potent, cell-permeable, non-tubulin-interacting mitosis inhibitor. Arrests mammalian cells in mitosis with monopolar spindles. In vitro, it specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein involved in the assembly and maintenance of the mitotic spindle (IC₅₀ = 14 mM). Purity: ³95% by HPLC.

Ref.: Kapoor, T.M., et al. 2000. J. Cell Biol.150, 975; Mayer, T.U., et al. 1999. Science286, 971.

Synonyms: 4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic Acid Ethyl Ester

C₁₄H₁₆N₂O₃S

CAS: not available

MDL: MFCD00813077

Molecular Weight: 292.4

Merck Index: not available

Specifications for EMD Inhibitor Monastrol 1MG 475879-1MG:

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