EMD Phenylarsine Oxide 250 Mg 521000-250MG w/ Free S&H

EMD Phenylarsine Oxide 250 Mg 521000-250MG is one of the many quality laboratory and scientific products we have to offer at very competitive pricing. EMD Phenylarsine Oxide 250 Mg 521000-250MG / 80055-378 is part of a wide selection of EMD Molecular biology and specialized reagents. Combining excellent quality with an affordable price, the EMD Phenylarsine Oxide 250 Mg 521000-250MG / 80055-378 can meet your scientific research needs while still offering a good value for a budget conscious end user. If you have any questions about any of our Molecular biology and specialized reagents please do not hesitate to contact our customer service for further guidance.

PAO; oxophenylarsine

White solid.A membrane-permeable protein tyrosine phosphatase inhibitor (IC₅₀=18µM). Stimulates 2-deoxyglucose transport in insulin-resistant human skeletal muscle and activates p56^lck protein tyrosine kinase. Blocks TNF-alpha-dependent activation of NF-kappaB in human myeloid ML-1a cells. PAO inhibits the protease activities of recombinant human caspases as well as endogenous caspases that are active in extracts of pre-apoptotic chicken DU249 cells (S/M extracts). At 100µM, it blocks the morphological changes of nuclear apoptosis in vitro and internucleosomal DNA fragmentation in S/M extracts without interfering with PARP or lamin A cleavage. Also known to cause complete and reversible inhibition of NADPH oxidase in human neutrophils.

Purity: >=95% by elemental analysis.Soluble in trichloromethane and DMSO.

FW: 168.0

CAS: 637-03-6

Merck Index: 12, 7083

Storage and Handling: Shipped as hazardous. Store at room temperature, 20°C (68°F).

Warning: Highly toxic. LD₅₀ of <=50mg/kg. May be carcinogenic/teratogenic.

Literature References: Takahashi, A., et al. 1997. Exp. Cell. Res. 231, 123; Carey, J.O., et al. 1995. Diabetes44, 1995; Le Cabec, V., and Maridonneau, Parini, I. 1995 J. Biol. Chem. 270, 2067.

Specifications for EMD Phenylarsine Oxide 250 Mg 521000-250MG:

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