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Liquid. In 100 mM NaCl, 50 mM MOPS, 5 mM DTT, 1 mM EDTA, 1 mM PMSF, pH 6.8. AVOID FREEZE/THAW CYCLES. Non-glycosylated and non-phosphorylated form of the 441-amino acid Tau splice variant. Tau is thought to promote normal microtubule assembly and stabilize microtubules in vivo. Hyperphosphorylated and glycated Tau tends to self-assemble and form paired helical fragments (PHFs), which are the basic structural components of neurofibrillary tangles (NFTs). NFT accumulation correlates with the clinical progression of Alzheimer’s disease. Purity: ³80% by SDS-PAGE. Sold on the basis of protein content.
Ref.: Johnson, G.V.W., and Hartigan, J.A. 1998. Alzheimier’s Disease Review3, 125; Mandelkow, E., et al. 1996. Ann. NY Acad. Sci.777, 96; Goedert, M. 1993. Trends Neurosci.16, 460; Lu, Q., et al. 1993. J Neurosci.13, 508.
Synonyms: not available
CAS: not available
MDL: MFCD02266274
Molecular Weight: 60,000
Merck Index: not available
| Description: | TAU HIS.TAG HUMAN RECOMBINA |
| Unit: | Each (50 UG) |